Spatial multi-omics characterization of neuroblastoma reveals ferroptosis-associated metabolic features in high-risk tumors

Abstract Background Neuroblastoma is a tumor of the sympathetic nervous system and is the most common extracranial solid malignancy in children. It displays striking clinical heterogeneity, ranging from spontaneous regression to a more aggressive, treatment resistant disease. While previous studies...

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Principais autores:	Cui Tu, Chin Wee Tan, James Monkman, Ana Clara Almeida, Gabrielle Antonio-Carreon, Natacha Omer, Giaan Hull, Kimberly Chung, Ahmed M. Mehdi, Antonietta Salerno, Orazio Vittorio, Aaron Mayer, Cleber Machado-Souza, Nanthini Jayabalan, Yi-Chin Toh, Hui Nee Hon, Fernanda de Almeida Brehm Pinhatti, Selene Elifio-Esposito, Wayne Nicholls, Lucia de Noronha, Arutha Kulasinghe, Fernando Souza-Fonseca-Guimaraes
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2026-03-01
Series:	Genome Medicine
Assuntos:	Neuroblastoma Multi-omics Ferroptosis Tumor microenvironment
Acceso en liña:	https://doi.org/10.1186/s13073-026-01622-0
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