Discovery of Potent PDE4 Inhibitors with 3(2H)-Pyridazinone Scaffold: Synthesis, In Silico Studies and In Vitro/Vivo Evaluation

Phospodiesterase 4 (PDE4) has long been an attractive target not only for the anti-inflammatory therapy in respiratory diseases, but also for other pathologies such as psoriatic arthritis and atopic dermatitis. In this study, we report the synthesis of 5-acetyl-2-ethyl-6-phenyl-3(2H)-pyridazinones d...

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Detalhes bibliográficos

Principais autores:	Claudia Vergelli, Letizia Crocetti, Gabriella Guerrini, Fabrizio Melani, Jordi Gracia, Maria Antonia Buil, Yolanda Garrido, Lluis Pagès, Joan Taltavull, Amadeu Gavaldà, Elena Calama, Maria Paola Giovannoni
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-02-01
coleção:	Molecules
Assuntos:	phosphodiesterases 4 inhibition selectivity in vivo test docking
Acesso em linha:	https://www.mdpi.com/1420-3049/31/4/699
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