IGF2BP3 regulates EMP1 stability in an m6A-dependent manner and activates the TGF-β pathway to promote pancreatic cancer invasion

Abstract Local invasion is considered a premonitor of tumor metastasis which cause curative difficulties and undesired prognosis in patients with Pancreatic ductal adenocarcinoma (PDAC). The importance of mRNA N6-methyladenosine (m6A) modification during tumor invasion is controversial as it plays d...

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Autores principales:	Long Liu, Yu Zhang, Yuxi Huang, Xiaohong Zhao, Hongxing Fu, Lin Chen, Qi Wang, Xingyu Liu, Xiang Zheng, Hengqing Zhu, Zheping Fang, Zhenzhen Gao, Sheng Yan
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Publishing Group 2025-11-01
Colección:	Cell Death and Disease
Acceso en línea:	https://doi.org/10.1038/s41419-025-08155-1
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