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Bactericidal activity does not predict sterilizing activity: the case of rifapentine in the murine model of Mycobacterium ulcerans disease.

Since 2004, treatment of Mycobacterium ulcerans disease, or Buruli ulcer, has shifted from surgery to daily treatment with streptomycin (STR) + rifampin (RIF) for 8 weeks. For shortening treatment duration, we tested the potential of daily rifapentine (RPT), a long-acting rifamycin derivative, as a...

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Autori principali: Deepak V Almeida, Paul J Converse, Si-Yang Li, Sandeep Tyagi, Eric L Nuermberger, Jacques H Grosset
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2013-01-01
Serie:PLoS Neglected Tropical Diseases
Accesso online:http://europepmc.org/articles/PMC3585034?pdf=render
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