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A practical guide to simulation for an adaptive trial design with a single interim analysis

Abstract Background The demand for adaptive trial designs is growing because of their flexibility and the potential for efficiency gains over traditional fixed designs. Adaptive trials allow planned modifications to the design based on accumulating data. Simulation is imperative in designing adaptiv...

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Hlavní autoři: Kaushala S. Jayawardana, Michael Dymock, Robert K. Mahar, Julie A. Marsh, Katherine J. Lee
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2025-10-01
Edice:Trials
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On-line přístup:https://doi.org/10.1186/s13063-025-09100-5
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