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A systematic review of randomised controlled trials with adaptive and traditional group sequential designs – applications in cardiovascular clinical trials

Abstract Background Trial design plays a key role in clinical trials. Traditional group sequential design has been used in cardiovascular clinical trials over decades as the trials can potentially be stopped early, therefore, it can reduce pre-planned sample size and trial resources. In contrast, tr...

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Detalhes bibliográficos
Principais autores: Jufen Zhang, Christy Saju
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2023-09-01
coleção:BMC Medical Research Methodology
Assuntos:
Acesso em linha:https://doi.org/10.1186/s12874-023-02024-1
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