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Single-cell RNA sequencing and AlphaFold 3 insights into cytokine signaling and its role in uveal melanoma

BackgroundUveal melanoma (UVM) is a form of eye cancer with a poor prognosis, particularly in metastatic patients. This study aimed to elucidate the cellular heterogeneity within UVM and identify prognostic biomarkers.MethodsWe performed single-cell RNA sequencing (scRNA-seq) on primary and metastat...

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Auteurs principaux: Hongyan Sun, Cunzi Li, Zuhui Pu, Ying Lu, Zijing Wu, Lan Zhou, Hongzhan Lin, Yumo Wang, Tao Zi, Lisha Mou, Ming-ming Yang
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2025-01-01
Collection:Frontiers in Immunology
Sujets:
uveal melanoma
single-cell RNA sequencing
cytokine signaling
T cell
AlphaFold 3
Dictionary of Immune Responses to Cytokines
Accès en ligne:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1458041/full
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