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Integrating genomics and AI to uncover molecular targets for mRNA vaccine development in lupus nephritis

Lupus nephritis (LN), a complex complication of systemic lupus erythematosus, requires in-depth cellular and molecular analysis for advanced treatment strategies, including mRNA vaccine development. In this study, we analyzed single-cell RNA sequencing data from 24 LN patients and 10 healthy control...

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Principais autores: Lisha Mou, Ying Lu, Zijing Wu, Zuhui Pu, Meiying Wang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-10-01
Serier:Frontiers in Immunology
Fag:
systemic lupus erythematosus
lupus nephritis
genomics
single cell
single-cell RNA sequencing
non-negative matrix factorization (NMF)
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1381445/full
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