The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient

<b>Background:</b> Mutations in bone morphogenetic protein receptor type II (BMPR2) are leading to the development of hereditary pulmonary arterial hypertension (PAH). In non-hereditary forms of PAH, perturbations in the transforming growth factor-β (TGF-β)/BMP-axis are believed to cause deficient B...

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Principais autores:	Chris Happé, Kondababu Kurakula, Xiao-Qing Sun, Denielli da Silva Goncalves Bos, Nina Rol, Christophe Guignabert, Ly Tu, Ingrid Schalij, Karien C. Wiesmeijer, Olga Tura-Ceide, Anton Vonk Noordegraaf, Frances S. de Man, Harm Jan Bogaard, Marie-José Goumans
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2020-06-01
Series:	Cells
Assuntos:	pulmonary arterial hypertension BMPR2 BMP and TGF-β signaling animal models of pulmonary hypertension
Acceso en liña:	https://www.mdpi.com/2073-4409/9/6/1422
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