Dissociation of the nuclear WWOX/TRAF2 switch renders UV/cold shock-mediated nuclear bubbling cell death at low temperatures

Abstract Background Normal cells express functional tumor suppressor WW domain-containing oxidoreductase (WWOX), designated WWOXf. UV irradiation induces WWOXf cells to undergo bubbling cell death (BCD) — an event due to the accumulation of nuclear nitric oxide (NO) gas that forcefully pushes the nu...

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Detalhes bibliográficos

Principais autores:	Szu-Jung Chen, Cheng-Chang Tsai, Sing-Ru Lin, Ming-Hui Lee, Shenq-Shyang Huang, Han-Yan Zeng, Lu-Hai Wang, Ming-Fu Chiang, Hamm-Ming Sheu, Nan-Shan Chang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-10-01
coleção:	Cell Communication and Signaling
Assuntos:	WWOX UV Cold shock TRAF2 Molecular switch Signaling
Acesso em linha:	https://doi.org/10.1186/s12964-024-01866-6
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