IRG1 catalyzed energy metabolite itaconic acid restrains type I interferon-dependent immune responses by alkylation of TBK1

Summary: Perturbation of energy metabolism is an essential feature during infection and inflammation. TANK-binding kinase 1 (TBK1) is crucial for initiating the innate immune response against viral infection, although aberrant and ongoing TBK1 activation induces excessive production of type I interf...

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Κύριοι συγγραφείς:	Li Chai, Chaoqun Li, Xuefeng Wang, Yanyang Qin, Hemin Sun, Jie Du, Liu Yang, Dongmei Hu, Jianan Xiong, Zhiyuan Zhao, Rong Gong, Tao Wu, Meng Wu, Meng Nie, Jialin Gao, Jihui Jia, Chengjiang Gao, Wei Zhao, Huan Zhou, Dongwei Kang, Mutian Jia
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Elsevier 2025-10-01
Σειρά:	Cell Reports
Θέματα:	CP: Immunology
Διαθέσιμο Online:	http://www.sciencedirect.com/science/article/pii/S2211124725011076
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