IRG1 catalyzed energy metabolite itaconic acid restrains type I interferon-dependent immune responses by alkylation of TBK1

Summary: Perturbation of energy metabolism is an essential feature during infection and inflammation. TANK-binding kinase 1 (TBK1) is crucial for initiating the innate immune response against viral infection, although aberrant and ongoing TBK1 activation induces excessive production of type I interf...

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Auteurs principaux:	Li Chai, Chaoqun Li, Xuefeng Wang, Yanyang Qin, Hemin Sun, Jie Du, Liu Yang, Dongmei Hu, Jianan Xiong, Zhiyuan Zhao, Rong Gong, Tao Wu, Meng Wu, Meng Nie, Jialin Gao, Jihui Jia, Chengjiang Gao, Wei Zhao, Huan Zhou, Dongwei Kang, Mutian Jia
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2025-10-01
Collection:	Cell Reports
Sujets:	CP: Immunology
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2211124725011076
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