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The relative immunogenicity of 20-valent and 15-valent pneumococcal conjugate vaccines: A systematic review and network meta-analysis

Higher-valent pneumococcal conjugate vaccines (PCV) may reduce adult pneumococcal disease, but no head-to-head trials compare PCV20 vs. PCV15 in adults. We synthesized serotype-specific immunogenicity from randomized controlled trials using a network meta-analysis via the common comparator PCV13. Pu...

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Main Authors: Ilaria Valentini, Erika Alessandra Strangi, Gaia Baccarini, Claudia Martini, Monica Paoloni, Alice Mannocci, Chiara de Waure
Format: Artigo
Language:Inglês
Published: Taylor & Francis Group 2026-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
Pneumococcal conjugate vaccine
PCV20
PCV15
adults
network meta-analysis
immunogenicity
Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2026.2702726
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