Neuronal ACE1 knockout disrupts the hippocampal renin angiotensin system leading to memory impairment and vascular loss in normal aging

Angiotensin I converting enzyme (ACE1) maintains blood pressure homeostasis by converting angiotensin I into angiotensin II in the renin-angiotensin system (RAS). ACE1 is expressed in the brain, where an intrinsic RAS regulates complex cognitive functions including learning and memory. ACE1 has been...

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Үндсэн зохиолчид:	Sohee Jeon, Miranda A. Salvo, Alia O. Alia, Jelena Popovic, Mitchell Zagardo, Sidhanth Chandra, Malik Nassan, David Gate, Robert Vassar, Leah K. Cuddy
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2024-11-01
Цуврал:	Neurobiology of Disease
Нөхцлүүд:	Angiotensin-I converting enzyme Cerebrovasular dysfunction Alzheimer's disease Renin-angiotensin system Selective vulnerability
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S0969996124003310
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!