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Neuronal ACE1 knockout disrupts the hippocampal renin angiotensin system leading to memory impairment and vascular loss in normal aging

Angiotensin I converting enzyme (ACE1) maintains blood pressure homeostasis by converting angiotensin I into angiotensin II in the renin-angiotensin system (RAS). ACE1 is expressed in the brain, where an intrinsic RAS regulates complex cognitive functions including learning and memory. ACE1 has been...

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Автори: Sohee Jeon, Miranda A. Salvo, Alia O. Alia, Jelena Popovic, Mitchell Zagardo, Sidhanth Chandra, Malik Nassan, David Gate, Robert Vassar, Leah K. Cuddy
Формат: Artigo
Мова:Inglês
Опубліковано: Elsevier 2024-11-01
Серія:Neurobiology of Disease
Предмети:
Angiotensin-I converting enzyme
Cerebrovasular dysfunction
Alzheimer's disease
Renin-angiotensin system
Selective vulnerability
Онлайн доступ:http://www.sciencedirect.com/science/article/pii/S0969996124003310
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