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Targeting cGAS-STING-macrophage axis: a novel therapeutic horizon for renal fibrosis

Renal fibrosis, a pivotal pathological hallmark of chronic kidney disease (CKD), arises from persistent inflammatory responses and extracellular matrix (ECM) deposition. Emerging evidence indicates the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling pathway has exerted...

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Principais autores: Qi Wei, Kui Zhao, Fuyun Jia, Jing Zhou, Tianrui Liu, Shengwei Gao
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-04-01
Serier:Frontiers in Immunology
Fag:
cGAS-STING
inflammation
macrophages
renal fibrosis
targeted therapy
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1809851/full
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