Genome-Wide Association Study and Gene-Based Analysis of Participants With Hemophilia A and Inhibitors in the My Life, Our Future Research Repository

IntroductionUp to 30% of individuals with hemophilia A develop inhibitors to replacement factor VIII (FVIII), rendering the treatment ineffective. The underlying mechanism of inhibitor development remains poorly understood. The My Life, Our Future Research Repository (MLOF RR) has gathered F8 and F9...

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Autori principali:	Samuel Lessard, Chunla He, Deepak K. Rajpal, Katherine Klinger, Christine Loh, Tim Harris, Jennifer Dumont
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2022-06-01
Serie:	Frontiers in Medicine
Soggetti:	genome-wide association study inhibitors humans whole-genome sequencing major histocompatibility complex hemophilia A
Accesso online:	https://www.frontiersin.org/articles/10.3389/fmed.2022.903838/full
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