Genome-Wide Association Study and Gene-Based Analysis of Participants With Hemophilia A and Inhibitors in the My Life, Our Future Research Repository

IntroductionUp to 30% of individuals with hemophilia A develop inhibitors to replacement factor VIII (FVIII), rendering the treatment ineffective. The underlying mechanism of inhibitor development remains poorly understood. The My Life, Our Future Research Repository (MLOF RR) has gathered F8 and F9...

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主要な著者:	Samuel Lessard, Chunla He, Deepak K. Rajpal, Katherine Klinger, Christine Loh, Tim Harris, Jennifer Dumont
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2022-06-01
シリーズ:	Frontiers in Medicine
主題:	genome-wide association study inhibitors humans whole-genome sequencing major histocompatibility complex hemophilia A
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fmed.2022.903838/full
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