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FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo.

BACKGROUND: The molecular mechanisms that are involved in the growth and invasiveness of osteosarcoma, an aggressive and invasive primary bone tumor, are not fully understood. The transcriptional co-factor FHL2 (four and a half LIM domains protein 2) acts as an oncoprotein or as a tumor suppressor d...

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Principais autores: Julia Brun, François-Xavier Dieudonné, Caroline Marty, Judith Müller, Roland Schüle, Ana Patiño-García, Fernando Lecanda, Olivia Fromigué, Pierre J Marie
格式: Artigo
語言:Inglês
出版: Public Library of Science (PLoS) 2013-01-01
叢編:PLoS ONE
在線閱讀:http://europepmc.org/articles/PMC3557236?pdf=render
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