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Genetic susceptibility to PM2.5 exposure and transcriptional responses in pediatric asthma: insights from single-cell transcriptomics

BackgroundExposure to fine particulate matter (PM2.5) increases asthma severity and reduces glucocorticoid responsiveness in children, yet the molecular mechanisms underlying PM2.5 sensitivity remain unclear. We previously identified a PM2.5-sensitive asthma phenotype and developed a PM2.5 sensitivi...

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Principais autores: Jelte Kelchtermans, Huiqi Qu, Cuiping Hou, Frank Mentch, Sharon A. McGrath-Morrow, Hakon Hakonarson
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2026-02-01
叢編:Frontiers in Immunology
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在線閱讀:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1644537/full
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