Genetic susceptibility to PM2.5 exposure and transcriptional responses in pediatric asthma: insights from single-cell transcriptomics

BackgroundExposure to fine particulate matter (PM2.5) increases asthma severity and reduces glucocorticoid responsiveness in children, yet the molecular mechanisms underlying PM2.5 sensitivity remain unclear. We previously identified a PM2.5-sensitive asthma phenotype and developed a PM2.5 sensitivi...

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Bibliografische Detailangaben

Hauptverfasser:	Jelte Kelchtermans, Huiqi Qu, Cuiping Hou, Frank Mentch, Sharon A. McGrath-Morrow, Hakon Hakonarson
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-02-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	asthma gene-environment interaction PM2.5 single-cell transcriptomics susceptibility
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1644537/full
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