ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK

Hyperactivation of Bruton’s tyrosine kinase (BTK) or interleukin-2-inducible T cell kinase (ITK) has been attributed to the pathogenesis of B-cell lymphoma or T-cell leukemia, respectively, which suggests that Bruton’s tyrosine kinase and interleukin-2-inducible T cell kinase are critical targets fo...

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Автори:	Peiran Song, Gang Bai, Shingpan Chan, Tao Zhang, Linjiang Tong, Yi Su, Yanyan Shen, Yi Chen, Yingqiang Liu, Mengzhen Lai, Yi Ning, Haotian Tang, Yan Fang, Ke Ding, Jian Ding, Hua Xie
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2022-12-01
Серія:	Frontiers in Pharmacology
Предмети:	Bruton’s tyrosine kinase interleukin-2-inducible T cell kinase ASK120067 B-cell lymphoma T-cell leukemia
Онлайн доступ:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1071114/full
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ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK

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