Design, synthesis and evaluation of a series of potential prodrugs of a Bruton’s tyrosine kinase (BTK) inhibitor

BTK has become a particularly attractive therapeutic target in autoimmune diseases and B-cell malignancies, making BTK inhibitors a valuable and important therapeutic option. We present the design, synthesis, and evaluation of a series of prodrugs of a BTK inhibitor with an insoluble 2,5-diaminopyri...

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Hauptverfasser:	Zhou-Peng Xiao, Min Liao, Xue-Juan Huang, Yu-Tong Wang, Xiao-Cui Lan, Xue-Ying Wang, Xi-Tao Li
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2023-03-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	prodrug BTK-bruton’s tyrosine kinase inhibitor solubility DFG-out
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1162216/full
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