Modelling APOL1-mediated kidney inflammation and fibrosis using a partially reprogrammed urine-derived SIX2-positive renal progenitor cell line

Abstract Background CKD affects approximately 850 million people worldwide and is a leading cause of mortality. Podocytes, cells in the kidney are terminally differentiated and incapable of division in vivo making the establishment of primary cultures particularly challenging. The ability of cells t...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Chantelle Thimm, Rosanne Mack, Osmond Adjei-Aruna, Wasco Wruck, Dalvir Kular, Ania Koziell, Kate Bramham, James Adjaye
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-11-01
Schriftenreihe:	Stem Cell Research & Therapy
Schlagworte:	Partial reprogramming Rejuvenation Nephrogenesis Interferon-γ Baricitinib JAK/STAT signaling pathway
Online-Zugang:	https://doi.org/10.1186/s13287-025-04710-x
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!