Centrioles are frequently amplified in early B cell development but dispensable for humoral immunity

Abstract Centrioles define centrosome structure and function. Deregulation of centriole numbers can cause developmental defects and cancer. The p53 tumor suppressor limits the growth of cells lacking or harboring additional centrosomes and can be engaged by the “mitotic surveillance” or the “PIDDoso...

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Autors principals:	Marina A. Schapfl, Gina M. LoMastro, Vincent Z. Braun, Maretoshi Hirai, Michelle S. Levine, Eva Kiermaier, Verena Labi, Andrew J. Holland, Andreas Villunger
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2024-10-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-024-53222-4
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