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C-terminal interleukin 1 alpha (IL-1α) overexpression drives EMT and a vulnerability to ferroptosis in HNSCC

High tumor expression of the cytokine interleukin-1 alpha (IL-1α) is associated with an aggressive tumor phenotype and poor clinical outcomes in head and neck squamous cell carcinoma (HNSCC). However, the mechanism behind IL-1α-induced tumor aggressiveness is unclear. The goal of this work is to inv...

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Main Authors: Ishrat Nourin Khan, Krishna Awasthi, Ziyu Wang, Nafis Md Irfan, Jay Saepoo, Joan N. Whittier, Nurgul Koyuncu, Md Roman Mogal, M.M. Hasibuzzaman, Shujie Yang, Michael Petronek, Andrean L. Simons
Format: Artigo
Language:Inglês
Published: Elsevier 2026-06-01
Series:Redox Biology
Subjects:
HNSCC
IL-1α
Ferroptosis
EMT
EGFR
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231726001709
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