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Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease

Summary: There are several established biomarkers for coronary heart disease (CHD), including blood pressure, cholesterol, and lipoproteins. It is of high interest to determine how a combined polygenic risk score (PRS) of CHD-associated biomarkers (BioPRS) can further improve genetic prediction of C...

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Autori principali: Jake Lin, PhD, Nina Mars, PhD, Yu Fu, MSc, Pietari Ripatti, PhD, Tuomo Kiiskinen, MD, Taru Tukiainen, PhD, Samuli Ripatti, PhD, Matti Pirinen, PhD
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2023-12-01
Serie:JACC: Basic to Translational Science
Soggetti:
biomarkers
coronary heart disease
genomics
GWAS
polygenic risk scores
Accesso online:http://www.sciencedirect.com/science/article/pii/S2452302X23002875
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