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Structure-guided development of heterodimer-selective GPCR ligands

G protein-coupled receptors (GPCRs) are involved in key signalling pathways and represent important targets for the treatment of neurological and psychiatric disorders. Here, the authors describe powerful bivalent ligands that efficiently bind to therapeutically relevant GPCR heterodimers

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Bibliografske podrobnosti
Principais autores: Harald Hübner, Tamara Schellhorn, Marie Gienger, Carolin Schaab, Jonas Kaindl, Laurin Leeb, Timothy Clark, Dorothee Möller, Peter Gmeiner
Format: Artigo
Jezik:Inglês
Izdano: Nature Portfolio 2016-07-01
Serija:Nature Communications
Online dostop:https://doi.org/10.1038/ncomms12298
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