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Structural insights into the catalytic mechanism of the microcystin tailoring enzyme McyI

Abstract The most common cyanotoxin microcystin is a cyclic heptapeptide produced by non-ribosomal peptide-polyketide synthetases and tailoring enzymes. The tailoring enzyme McyI, a 2-hydroxyacid dehydrogenase, converts (3-methyl)malate into (3-methyl)oxaloacetate to produce the non-proteinogenic am...

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Bibliografische gegevens
Hoofdauteurs: Xiao Wang, Yue Yin, Wen-Long Cheng, Ya-Fei Duan, Yu-Shuai Li, Jia Wang, Mingzhu Wang, Huai-En Dai, Lin Liu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Portfolio 2025-04-01
Reeks:Communications Biology
Online toegang:https://doi.org/10.1038/s42003-025-08008-9
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