Structural insights into the catalytic mechanism of the microcystin tailoring enzyme McyI
Abstract The most common cyanotoxin microcystin is a cyclic heptapeptide produced by non-ribosomal peptide-polyketide synthetases and tailoring enzymes. The tailoring enzyme McyI, a 2-hydroxyacid dehydrogenase, converts (3-methyl)malate into (3-methyl)oxaloacetate to produce the non-proteinogenic am...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Portfolio
2025-04-01
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| Серии: | Communications Biology |
| Online-ссылка: | https://doi.org/10.1038/s42003-025-08008-9 |
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