Phase Separation Competent TIA1 Couples Glycolytic Shutdown to CD8⁺ T-Cell Activation and Shapes the Efficacy of Intravesical BCG in Bladder Cancer

Metabolic immune evasion is a major factor limiting the long-term efficacy of intravesical Bacillus Calmette–Guérin (BCG) therapy in non-muscle-invasive bladder cancer (NMIBC). TIA1 is a stress granule RNA-binding protein with liquid–liquid phase separation (LLPS) capacity. Its role in tumor metabol...

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Bibliografiset tiedot

Päätekijät:	Wenwen Zhang, Kailiang Zhou, Pinru Chen, Xuanshuang Du, Min Liu
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	MDPI AG 2025-11-01
Sarja:	Biology
Aiheet:	TIA1 liquid–liquid phase separation glycolysis CD8<sup>+</sup> T cells Bacillus Calmette–Guérin bladder cancer
Linkit:	https://www.mdpi.com/2079-7737/14/11/1576
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