Dysfunctional mitochondria trap proteins in the intermembrane space
Abstract The accumulation of mitochondrial precursor proteins in the cytosol due to mitochondrial dysfunction compromises cellular proteostasis and is a hallmark of diseases. Why non-imported precursors are toxic and how eukaryotic cells prevent their accumulation in the cytosol is still poorly unde...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Springer Nature
2025-06-01
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| Series: | The EMBO Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s44318-025-00486-1 |
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