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Dysfunctional mitochondria trap proteins in the intermembrane space

Abstract The accumulation of mitochondrial precursor proteins in the cytosol due to mitochondrial dysfunction compromises cellular proteostasis and is a hallmark of diseases. Why non-imported precursors are toxic and how eukaryotic cells prevent their accumulation in the cytosol is still poorly unde...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tamara Flohr, Markus Räschle, Johannes M Herrmann
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Nature 2025-06-01
Cyfres:The EMBO Journal
Pynciau:
Mynediad Ar-lein:https://doi.org/10.1038/s44318-025-00486-1
Tagiau: Ychwanegu Tag
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