Increase of Synergistic Secondary Antiviral Mutations in the Evolution of A(H1N1)pdm09 Influenza Virus Neuraminidases

The unexpected emergence of oseltamivir-resistant A(H1N1) viruses in 2008 was facilitated in part by the establishment of permissive secondary neuraminidase (NA) substitutions that compensated for the fitness loss due to the NA-H275Y resistance substitution. These viruses were replaced in 2009 by os...

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Auteurs principaux:	Susanne C. Duwe, Jeanette Milde, Alla Heider, Marianne Wedde, Brunhilde Schweiger, Ralf Dürrwald
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2024-07-01
Collection:	Viruses
Sujets:	influenza viruses A(H1N1)pdm09 neuraminidase inhibitor surveillance resistance monitoring
Accès en ligne:	https://www.mdpi.com/1999-4915/16/7/1109
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