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Increase of Synergistic Secondary Antiviral Mutations in the Evolution of A(H1N1)pdm09 Influenza Virus Neuraminidases

The unexpected emergence of oseltamivir-resistant A(H1N1) viruses in 2008 was facilitated in part by the establishment of permissive secondary neuraminidase (NA) substitutions that compensated for the fitness loss due to the NA-H275Y resistance substitution. These viruses were replaced in 2009 by os...

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Principais autores: Susanne C. Duwe, Jeanette Milde, Alla Heider, Marianne Wedde, Brunhilde Schweiger, Ralf Dürrwald
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2024-07-01
coleção:Viruses
Assuntos:
influenza viruses
A(H1N1)pdm09
neuraminidase inhibitor
surveillance
resistance
monitoring
Acesso em linha:https://www.mdpi.com/1999-4915/16/7/1109
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