Toll-Like Receptor 9 Promotes Cardiac Inflammation and Heart Failure during Polymicrobial Sepsis

Background. Aim was to elucidate the role of toll-like receptor 9 (TLR9) in cardiac inflammation and septic heart failure in a murine model of polymicrobial sepsis. Methods. Sepsis was induced via colon ascendens stent peritonitis (CASP) in C57BL/6 wild-type (WT) and TLR9-deficient (TLR9-D) mice. Ba...

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Hauptverfasser:	Ralph Lohner, Markus Schwederski, Carolin Narath, Johanna Klein, Georg D. Duerr, Alexandra Torno, Pascal Knuefermann, Andreas Hoeft, Georg Baumgarten, Rainer Meyer, Olaf Boehm
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2013-01-01
Schriftenreihe:	Mediators of Inflammation
Online-Zugang:	http://dx.doi.org/10.1155/2013/261049
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