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A Unique Chimeric RNA: ERCC1‐iASPP Drives Benzo[a]pyrene‐Induced Lung Carcinogenesis via Dual Coding and Non‐Coding Mechanisms

Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic aromatic hydrocarbon (PAH) carcinogen. The adjacent genes ERCC1 and iASPP within this locus respectively co...

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Autores principales: Mingming Shan, Mingyang Xiao, Liang Zhang, Shen Wang, Jiahang Wu, Kang Cao, Yujin Li, Guopei Zhang, Junwei Xie, Xiaobo Lu
Formato: Artigo
Lenguaje:Inglês
Publicado: Wiley 2026-02-01
Colección:Advanced Science
Materias:
bifunctional RNA
chimeric RNA
ERCC1‐iASPP
lung cancer
malignant transformation
polycyclic aromatic hydrocarbons
Acceso en línea:https://doi.org/10.1002/advs.202507217
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