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Recent Advances in SARS-CoV-2 Main Protease Inhibitors: From Nirmatrelvir to Future Perspectives

The main protease (M<sup>pro</sup>) plays a pivotal role in the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target. Disruption of the catalytic activity of M<sup>pro</sup> produces a detrimental effect on the course of the in...

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Principais autores: Andrea Citarella, Alessandro Dimasi, Davide Moi, Daniele Passarella, Angela Scala, Anna Piperno, Nicola Micale
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-09-01
Serier:Biomolecules
Fag:
COVID-19
SARS-CoV-2 M<sup>pro</sup>
protease inhibitors
coronavirus
peptidomimetics
Paxlovid
Online adgang:https://www.mdpi.com/2218-273X/13/9/1339
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