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Evolution of mutations in the ftsI gene leading to amino acid substitutions in PBP3 in Haemophilus influenzae strains under the selective pressure of ampicillin and cefuroxime

Background: Aminopenicillins are recommended agents for non-invasive Haemophilus influenzae infections. One of the mechanisms of resistance to β-lactams is the alteration of the transpeptidase region of penicillin binding protein 3 (PBP3) which is caused by mutations in the ftsI gene. It was shown t...

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Principais autores: Vladislav Jakubu, Iveta Vrbova, Ibrahim Bitar, Marketa Cechova, Lucia Malisova, Helena Zemlickova
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2024-09-01
Series:International Journal of Medical Microbiology
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Acceso en liña:http://www.sciencedirect.com/science/article/pii/S1438422124000304
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