Simultaneous profiling of the blood and gut T and B cell repertoires in Crohn’s disease and symptomatic controls illustrates tissue-specific alterations in the immune repertoire of individuals with Crohn’s disease

IntroductionCrohn’s disease (CD) is a clinical subset of inflammatory bowel disease that is characterized by patchy transmural inflammation across the gastrointestinal tract. Although the exact etiology remains unknown, recent findings suggest that it is a complex multifactorial disease with contrib...

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Hauptverfasser:	Aya K. H. Mahdy, Valentina Schöpfel, Gert Huppertz-Hauss, Gøri Perminow, Florian Tran, Corinna Bang, Johannes R. Hov, May-Bente Bengtson, Petr Ricanek, Randi Opheim, Tone Bergene Aabrekk, Trond Espen Detlie, Vendel A. Kristensen, Mathilde Poyet, Marte Lie Høivik, Andre Franke, Hesham ElAbd
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2025-09-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	IBD - inflammatory bowel disease T cell repertoire B cell repertoire immune repertoire analysis colon immune repertoire blood immune repertoire
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1638522/full
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