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Cell-cell and cell-matrix adhesion in survival and metastasis: Stat3 versus Akt

Both cell-cell and cell-matrix adhesion are important for epithelial cell differentiation and function. Classical cadherins mediate cell to cell interactions and are potent activators of the signal transducer and activator of transcription (Stat3), thereby offering survival signaling. While the epit...

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Principais autores: Niit Maximilian, Hoskin Victoria, Carefoot Esther, Geletu Mulu, Arulanandam Rozanne, Elliott Bruce, Raptis Leda
Format: Artigo
Sprog:Inglês
Udgivet: De Gruyter 2015-12-01
Serier:Biomolecular Concepts
Fag:
akt
apoptosis
cadherins
cdc42
emt
fak
il-6
metastasis
rac
signal transducer and activator of transcription-3
Online adgang:https://doi.org/10.1515/bmc-2015-0022
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