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An activity-based probe for antimicrobial target DXP synthase, a thiamin diphosphate-dependent enzyme

This work reports an alkyl acetylphosphonate (alkylAP) activity-based probe (ABP) for 1-deoxy-d-xylulose 5-phosphate synthase DXPS, a promising antimicrobial target. This essential thiamin diphosphate (ThDP)-dependent enzyme operates at a branchpoint in bacterial central metabolism and is believed t...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Lauren B. Coco, Caren L. Freel Meyers
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2024-05-01
Schriftenreihe:Frontiers in Chemical Biology
Schlagworte:
1-deoxy-D-xylulose 5-phosphate synthase
activity-based probe
alkyl acetylphosphonate
thiamin-dependent enzyme
antimicrobial target
vitamin biosynthesis
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fchbi.2024.1389620/full
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