An activity-based probe for antimicrobial target DXP synthase, a thiamin diphosphate-dependent enzyme
This work reports an alkyl acetylphosphonate (alkylAP) activity-based probe (ABP) for 1-deoxy-d-xylulose 5-phosphate synthase DXPS, a promising antimicrobial target. This essential thiamin diphosphate (ThDP)-dependent enzyme operates at a branchpoint in bacterial central metabolism and is believed t...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Frontiers Media S.A.
2024-05-01
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| Col·lecció: | Frontiers in Chemical Biology |
| Matèries: | |
| Accés en línia: | https://www.frontiersin.org/articles/10.3389/fchbi.2024.1389620/full |
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