Senescent endothelial cell-derived extracellular vesicles promote neoadjuvant chemoresistance in colorectal cancer via GPX4

Abstract Chemotherapy resistance remains a major challenge in advanced colorectal cancer (CRC), with chemotherapy-induced senescence playing a key role. While cancer cell senescence has been extensively studied, the contribution of stromal components, particularly vascular endothelial cells, remains...

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Hlavní autoři:	Kunpeng Jia, Yuxin Ding, Menglei Jin, Qi Yang, Xinyu Wang, Yujie Yan, Jiao Xiang, Ruoqi Zhang, Jun Fang, Jingxin Jiang, Danting Wang, Fengbo Huang, Jianming Hu, Jian Huang, Yeting Hu, Zhigang Chen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-05-01
Edice:	Communications Biology
On-line přístup:	https://doi.org/10.1038/s42003-026-10183-2
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!