Senescent endothelial cell-derived extracellular vesicles promote neoadjuvant chemoresistance in colorectal cancer via GPX4

Abstract Chemotherapy resistance remains a major challenge in advanced colorectal cancer (CRC), with chemotherapy-induced senescence playing a key role. While cancer cell senescence has been extensively studied, the contribution of stromal components, particularly vascular endothelial cells, remains...

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Detalhes bibliográficos

Principais autores:	Kunpeng Jia, Yuxin Ding, Menglei Jin, Qi Yang, Xinyu Wang, Yujie Yan, Jiao Xiang, Ruoqi Zhang, Jun Fang, Jingxin Jiang, Danting Wang, Fengbo Huang, Jianming Hu, Jian Huang, Yeting Hu, Zhigang Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-05-01
coleção:	Communications Biology
Acesso em linha:	https://doi.org/10.1038/s42003-026-10183-2
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