FAK inhibition alone or in combination with adjuvant therapies reduces cancer stem cell activity

Abstract Cancer stem-like cells (CSC) contribute to therapy resistance and recurrence. Focal adhesion kinase (FAK) has a role in CSC regulation. We determined the effect of FAK inhibition on breast CSC activity alone and in combination with adjuvant therapies. FAK inhibition reduced CSC activity and...

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Bibliografische Detailangaben

Hauptverfasser:	Simon Timbrell, Hosam Aglan, Angela Cramer, Phil Foden, David Weaver, Jonathan Pachter, Aoife Kilgallon, Robert B. Clarke, Gillian Farnie, Nigel J. Bundred
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2021-05-01
Schriftenreihe:	npj Breast Cancer
Online-Zugang:	https://doi.org/10.1038/s41523-021-00263-3
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