Characterization of <i>O</i>-Glycosylation and <i>N</i>-Glycosylation in Bispecific Antibodies and Its Importance in Therapeutic Antibody Development

<b>Background/Objectives</b>: This study comprehensively characterized the <i>O</i>- and <i>N</i>-glycosylation profiles of bispecific antibodies (BsAbs) via advanced analytical techniques to evaluate their structural and functional implications. <b>Methods</b>: High-resolution MS revealed <i>O</i>-...

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Auteurs principaux:	Maoqin Duan, Luyun Guo, Zhen Long, Yongbo Ni, Yalan Yang, Jialiang Du, Meng Li, Jialing Zhang, Tao Tang, Chuanfei Yu, Lan Wang
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2025-10-01
Collection:	Pharmaceuticals
Sujets:	BsAbs <i>O</i>-glycosylation <i>N</i>-glycosylation MS HILIC-HPLC HPAEC-PAD
Accès en ligne:	https://www.mdpi.com/1424-8247/18/10/1538
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