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Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome

Abstract Background Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope prot...

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Principais autores: Florian Köhler, Felix Bormann, Günter Raddatz, Julian Gutekunst, Samuel Corless, Tanja Musch, Anke S. Lonsdorf, Sylvia Erhardt, Frank Lyko, Manuel Rodríguez-Paredes
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-05-01
coleção:Genome Medicine
Assuntos:
Hutchinson-Gilford progeria syndrome
Epigenetics
Aging
Lamina-associated domains (LADs)
DNA methylation
Chromatin accessibility
Acesso em linha:http://link.springer.com/article/10.1186/s13073-020-00749-y
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