ABC Transporters in Human Diseases

Mammalian ATP-binding cassette (ABC) transporters constitute a superfamily of proteins involved in many essential cellular processes. Most of these transporters are transmembrane proteins and allow the active transport of solutes, small molecules, and lipids across biological membranes. On the one h...

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Enregistré dans:
Détails bibliographiques
Collectivité auteur: Falguières, Thomas
Format: Livro
Langue:Inglês
Publié: MDPI - Multidisciplinary Digital Publishing Institute 2022
Sujets:
bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
ABC transporters
drug action
regulatory extension
regulatory insertion
mechanism of action
MRP1
MRP4
breast cancer
proliferation
migration
invasion
cAMP
ABCG2
ABCB1
blood-brain barrier
PET
Alzheimer’s disease
beta-amyloid
tariquidar
erlotinib
ABCG5
ABCG8
ATP-binding cassette transporter
cholesterol
polar relay
sitosterolemia
5′ untranslated region
cis-acting elements
ABCA subfamily
bioinformatics
ABC transporter
therapy response
disease-free survival
next-generation sequencing
competitive allele-specific PCR
P-glycoprotein
amyloid-beta
neuron
SK-N-SH
gene therapy
AAV
PFIC
BSEP
ABCB11
bile salts
intrahepatic cholestasis
chaperones
PFIC2
BRIC
ATP-binding cassette transporter A1 (ABCA1)
cholesterol homeostasis
reverse cholesterol transport
HDL-C
dyslipidemia
type 2 diabetes
microparticles
ABCG2 genotype
clinico-genetic analysis
ethnic specificity
genetic variations
precision medicine
rare variant
Roma
serum uric acid
SUA-lowering therapy
urate transporter
bile secretion
ABCB4
ABCC2
ABCG5/G8
molecular partners
phytosterol
xenosterol
atherosclerosis
gall stone
ABC
transporter
ABC (ATP-binding cassette) transporters
multidrug resistance
transport
trafficking
urate
mutations
polymorphisms
ABCC6
TNAP
NT5E
Pseudoxanthoma elasticum (PXE)
cancer
membrane protein
functional divergence
calcification
pseudoxanthoma elasticum
generalized arterial calcification of infancy
pyrophosphate
therapies
ABCA7
phagocytosis
Aβ peptides
yeast
multidrug transporter
anticancer
antifungal resistance
mechanism
peroxisome
adrenoleukodystrophy
fatty acids
gout
early-onset gout
hyperuricemia
uric acid
BCRP
single nucleotide polymorphism
SNP
homology modeling
substrate-binding site
cellular ATP efflux
mutagenesis
intracellular traffic
MDR3
phosphatidylcholine
RAB GTPase
taxol
drug transport
n/a
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