The impact of dysfunctional variants of ABCG2 on hyperuricemia and gout in pediatric-onset patients

Abstract Background ABCG2 is a high-capacity urate transporter that plays a crucial role in renal urate overload and extra-renal urate underexcretion. Previous studies have suggested an association between hyperuricemia and gout susceptibility relative to dysfunctional ABCG2 variants, with rs2231142...

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Main Authors: Blanka Stiburkova, Katerina Pavelcova, Marketa Pavlikova, Pavel Ješina, Karel Pavelka
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-03-01
Colecção:Arthritis Research & Therapy
Assuntos:
Gout
Hyperuricemia
Urate transport
ABCG2
Acesso em linha:http://link.springer.com/article/10.1186/s13075-019-1860-8
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http://link.springer.com/article/10.1186/s13075-019-1860-8

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